{"product_id":"cst-63403s","title":"CST,  63403S, MYH11 (E4N8M) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying MYH11. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, MYH11 (E4N8M) Rabbit Monoclonal Antibody (CST #63403) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunohistochemistry (Paraffin): 1:100 - 1:400\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 70661 .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMYH11 (E4N8M) Rabbit Monoclonal Antibody recognizes endogenous levels of total MYH11 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human MYH11 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nencodes the smooth muscle myosin heavy chain (SMMHC), a major specific contractile protein produced in smooth muscle (1). Mutations in cause medial degeneration of the aorta with very low smooth muscle cell (SMC) content. Disease symptoms include aortic stiffness, aneurysm\/dissection, and ductus arteriosus (2). One of the most frequent chromosomal translocations associated with acute myeloid leukemia (AML) is the fusion of , encoding the core binding protein CBFβ transcriptional factor, to (3). This gene fusion event results in a chimeric protein that suppresses the transactivation mediated by CBF\/AML-1, impairs the process of normal hematopoietic differentiation (4,5), and creates preleukemic myeloid progenitors that can be targets for AML transformation (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAAT4; DKFZp686D10126; DKFZp686D19237; epididymis secretory sperm binding protein; FAA4; FLJ35232; KIAA0866; MGC126726; MGC32963; MYH11; Myosin heavy chain 11; Myosin heavy chain, smooth muscle isoform; Myosin-11; myosin, heavy chain 11, smooth muscle; myosin, heavy polypeptide 11, smooth muscle; SMHC; SMMHC\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 270\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801033625769,"sku":"63403S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-63403s","provider":"Iright","version":"1.0","type":"link"}