{"product_id":"cst-64094t","title":"CST,  64094T, VEGF Receptor 1 (E7T9H) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying VEGFR1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, VEGF Receptor 1 (E7T9H) Rabbit Monoclonal Antibody (CST #64094) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nVEGF Receptor 1 (E7T9H) Rabbit Monoclonal Antibody recognizes endogenous levels of total VEGF Receptor 1 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a recombinant protein specific to the carboxy terminus of human VEGF Receptor 1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe vascular endothelial growth factor (VEGF) receptor (VEGFR-1, Flt-1) is a 180 kDa receptor tyrosine kinase belonging to the VEGFR (Flt) family (1-3). The receptor is comprised of seven extracellular Ig-like domains, a single transmembrane region and cytoplasmic tail containing the active kinase domain (1,2). VEGFR-1 plays an important role in endothelial cell function and normal vascular development, as well as in hematopoietic function (2,3). VEGF-A is a high affinity ligand of VEGFR-1. VEGFR-1 also binds VEGF-B and PLGF (2). Ligand binding results in very little VEGFR-1 kinase activation, and VEGFR-1\/VEGF-A binding negatively regulates VEGF function by diverting the growth factor from other functional VEGF receptors (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nFLT; FLT-1; FLT1; fms related receptor tyrosine kinase 1; fms related tyrosine kinase 1; Fms-like tyrosine kinase 1; fms-related tyrosine kinase 1 (vascular endothelial growth factor\/vascular permeability factor receptor); FRT; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; Vascular endothelial growth factor receptor 1; Vascular permeability factor receptor; VEGFR-1; VEGFR1; VGFR1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 180, 200\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799833432233,"sku":"64094T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-64094t","provider":"Iright","version":"1.0","type":"link"}