{"product_id":"cst-64210s","title":"CST,  64210S, Human IL-17A\/F Heterodimer Recombinant Protein","description":"Growth Factors and Cytokines for studying IL17F\/IL17A in the research area.\n\n\u003cb\u003eStorage\u003c\/b\u003e\nHuman IL-17A\/F Heterodimer Recombinant Protein is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg\/mL which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Once in solution, store at 4°C and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles if storing reconstituted material at -20ºC to -80ºC.\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nRecombinant human IL-17A\/F was expressed in and is supplied in a lyophilized form.\n\u003cb\u003eBackground\u003c\/b\u003e\nIL-17A\/F is a cystine-linked heterodimer of IL-17A and IL-17F (1,2). IL-17A\/F is produced by Th cells and γδ T cells (1,2). IL-17A\/F stimulates production of pro-inflammatory cytokines and neutrophil chemoattractants, thereby functioning as a bridge between adaptive and innate immunity (1-3). Some research studies suggest that IL-17A\/F may be involved in mucosal immunity against some bacterial infections and has a putative role in some autoimmune disorders (3,4). The receptor for IL-17A\/F consists of a heterodimer of IL-17RA and IL-17RC and signaling through this receptor leads to activation of the Erk1\/2 and NF-κB pathways (1).","brand":"CST","offers":[{"title":"Default Title","offer_id":46800715841705,"sku":"64210S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-64210s","provider":"Iright","version":"1.0","type":"link"}