{"product_id":"cst-64221s","title":"CST,  64221S, PP6C (E3V2A) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying PP6C. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, PP6C (E3V2A) Rabbit Monoclonal Antibody (CST #64221) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPP6C (E3V2A) Rabbit Monoclonal Antibody recognizes endogenous levels of total PP6C protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly243 of human PP6C protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nSerine\/threonine-protein phosphatase 6 (PP6) is an evolutionarily conserved and ubiquitously expressed member of the type 2A protein phosphatase family. Research studies have proposed that PP6 functions as a heterotrimeric holoenzyme complex that consists of a catalytic subunit, PP6C, and regulatory subunits (1,2). PP6 has been implicated in the regulation of numerous biological processes, such as cell-cycle progression, cell growth, and antiviral innate immune signaling (3). Indeed, research studies have demonstrated that PP6C dephosphorylates and activates Rig-I in order to facilitate type I interferon (IFN) signaling and antiviral immunity (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nFLJ92648; MGC12249; PP6; PP6C; PPP6; PPP6C; protein phosphatase 6 catalytic subunit; protein phosphatase 6, catalytic subunit; serine\/threonine protein phosphatase catalytic subunit; Serine\/threonine-protein phosphatase 6 catalytic subunit; Serine\/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 32\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799834185897,"sku":"64221S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-64221s","provider":"Iright","version":"1.0","type":"link"}