{"product_id":"cst-64370s","title":"CST,  64370S, Parvalbumin (E8N2U) Horse Chimeric Monoclonal Antibody","description":"Monoclonal Antibody for studying Parvalbumin mouse. Validated for Immunofluorescence (Frozen). Available in 2 sizes. Highly specific and rigorously validated in-house, Parvalbumin (E8N2U) Horse Chimeric Monoclonal Antibody (CST #64370) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nImmunofluorescence (Frozen): 1:50 - 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Immunofluorescence (Frozen)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nParvalbumin (E8N2U) Horse Chimeric Monoclonal Antibody recognizes endogenous levels of total parvalbumin protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nThis recombinant chimeric antibody is engineered from Parvalbumin (E8N2U) XP Rabbit mAb #80561 according to animal-free protocols. The chimeric antibody retains its antigen-binding Fab regions from the original rabbit monoclonal antibody but contains a horse-derived Fc domain. When multiplexing, Fc-directed rabbit secondaries are required to detect rabbit-host primary antibodies. The parent antibody, Parvalbumin (E8N2U) XP Rabbit mAb #80561, is produced by immunizing animals with a recombinant protein specific to the amino terminus of human parvalbumin protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nParvalbumin (PV, PVALB) is a member of the EF-hand family of calcium-binding proteins, containing EF-hand domains with a high affinity for calcium and magnesium (1). Parvalbumin is expressed in both the soma and in processes of specific subclasses of GABAergic interneurons. Parvalbumin is a slow calcium buffer, meaning it accelerates the initial phase of decay of calcium after an action potential, which likely inhibits facilitation and is thought to regulate short-term synaptic plasticity (2,3). Altered function of PV positive interneurons has been implicated in many neurological diseases, such as Alzheimer's disease, autism spectrum disorder, schizophrenia, and bipolar disorder (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nParv; parvalbumin; Parvalbumin alpha; PRVA; PV; Pva; Pvalb\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nSource\/Isotype: Horse chimeric IgG4","brand":"CST","offers":[{"title":"Default Title","offer_id":46800297492649,"sku":"64370S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-64370s","provider":"Iright","version":"1.0","type":"link"}