{"product_id":"cst-64414t","title":"CST,  64414T, Transketolase (E7O4M) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying Transketolase. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Transketolase (E7O4M) Rabbit Monoclonal Antibody (CST #64414) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nTransketolase (E7O4M) Rabbit Monoclonal Antibody recognizes endogenous levels of total transketolase protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val296 of human transketolase protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nTransketolase (TKT) is a homodimer in the pentose phosphate pathway (PPP) that catalyzes the interketol transfer between ketoses and aldoses (1,2). This enzyme, along with transaldolase, connects the nonoxidative branch of the PPP with glycolysis (1-3). Several regions of TKT are evolutionarily conserved from gram-negative bacteria to mammals (3). There is evidence that hypoxic (4) and non-hypoxic induction of HIF1-α (5) increases the expression of TKT. Because cancer cells rely on TKT in altered cell metabolism for nucleic acid synthesis, work has been done to develop inhibitors of TKT as novel cancer treatments (5-8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nepididymis luminal protein 107; epididymis secretory protein Li 48; FLJ34765; HEL-S-48; HEL107; SDDHD; TK; TKT; TKT1; Transketolase\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 68\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799835234473,"sku":"64414T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-64414t","provider":"Iright","version":"1.0","type":"link"}