{"product_id":"cst-65575t","title":"CST,  65575T, PDP1 (D8Y6L) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying PDP1. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, PDP1 (D8Y6L) Rabbit Monoclonal Antibody (CST #65575) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPDP1 (D8Y6L) Rabbit Monoclonal Antibody recognizes endogenous levels of total PDP1 protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu327 of human PDP1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nPyruvate dehydrogenase (PDH) catalyzes decarboxylation of the glycolytic intermediate pyruvate to acetyl-CoA (1). Acetyl-CoA is further metabolized in the tricarboxylic acid (TCA) cycle to generate ATP and NADH (1). Pyruvate dehydrogenase kinase 1 (PDHK1) phosphorylates PDH to suppress its activity, while pyruvate dehydrogenase phosphatase 1 (PDP1) dephosphorylates PDH to enhance its activity (1). Phosphorylation of PDP1 at Tyr94 inhibits PDP1 and has been shown to be present in a variety of cancer cell lines and primary human leukemia cells (2).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; FLJ32517; FLJ56179; MGC119646; PDH; PDP; PDP 1; PDP1; PDPC; PDPC 1; PPM2A; PPM2C; Protein phosphatase 2C; protein phosphatase 2C, magnesium-dependent, catalytic subunit; protein phosphatase, Mg2+\/Mn2+ dependent 2A; pyruvate dehydrogenase (Lipoamide) phosphatase-phosphatase; Pyruvate dehydrogenase phosphatase catalytic subunit 1; pyruvate dehyrogenase phosphatase catalytic subunit 1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 55\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799841165481,"sku":"65575T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-65575t","provider":"Iright","version":"1.0","type":"link"}