{"product_id":"cst-65883s","title":"CST,  65883S, G-CSF (E9S2E) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying G-CSF. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, G-CSF (E9S2E) Rabbit Monoclonal Antibody (CST #65883) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nG-CSF (E9S2E) Rabbit Monoclonal Antibody recognizes endogenous levels of total G-CSF protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to full-length human G-CSF protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nGranulocyte colony-stimulating factor (G-CSF) is a hematopoietic cytokine essential for neutrophil development, survival, and egress from bone marrow (1-4). Macrophages and monocytes are the predominant producers of G-CSF (3), and endothelial cells, fibroblasts, and neuronal cells can produce G-CSF in response to inflammatory stimuli (3). G-CSF inhibits apoptosis in neutrophils and neurons (4,5). G-CSF stimulates proliferation and differentiation of neuronal progenitor cells (5). G-CSF binding to G-CSFR induces receptor dimerization and activation of Jak1\/2 tyrosine phosphorylation (3,6). Signaling is through Stat3, ERK, p38, and Akt (5,6). Absence of functional G-CSF or its receptor in humans and mice causes neutropenia (7,8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nC17orf33; colony stimulating factor 3; colony stimulating factor 3 (granulocyte); CSF3; CSF3OS; Filgrastim; G-CSF; GCSF; Granulocyte colony-stimulating factor; granulocyte-colony stimulating factor; Lenograstim; Pluripoietin\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 15\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799843229865,"sku":"65883S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-65883s","provider":"Iright","version":"1.0","type":"link"}