{"product_id":"cst-66000s","title":"CST,  66000S, SENP6 (F2K4K) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying SENP6. Validated for Western Blotting,Simple Western™,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, SENP6 (F2K4K) Rabbit Monoclonal Antibody (CST #66000) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nSimple Western™: 1:50 - 1:250\nImmunoprecipitation: 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nSENP6 (F2K4K) Rabbit Monoclonal Antibody recognizes endogenous levels of total SENP6 protein. This antibody may detect a band of unknown origin at 80 kDa in some cell lines.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly842 of human SENP6 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nSUMOylation is a post-translational modification (PTM) that involves the covalent attachment of small ubiquitin-related modifier (SUMO) proteins to substrate proteins. SUMOylation is a reversible process that can be erased by SUMO-specific proteases (SENPs) (1). SENP6 is a critical factor for cell cycle progression and survival (2-4). SENP6 has been shown to deconjugate SUMO2\/3 polymers on a group of DNA damage response proteins and is required for maintaining genomic stability (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n2810017C20Rik; FLJ11355; FLJ11887; KIAA0389; KIAA0797; SENP6; Sentrin-specific protease 6; Sentrin\/SUMO-specific protease SENP6; SSP1; SUMO specific peptidase 6; SUMO-1-specific protease 1; SUMO1\/sentrin specific peptidase 6; SUMO1\/sentrin specific protease 6; SUSP1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 150\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799844016297,"sku":"66000S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-66000s","provider":"Iright","version":"1.0","type":"link"}