{"product_id":"cst-66244s","title":"CST,  66244S, GSK343","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nGSK343 is supplied as a lyophilized powder. For a 5 mM stock, reconstitute the 1 mg in 369.21 μl DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used at 5 nM-5 μM for 2-48 hr.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized or in solution at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles.\n\u003cb\u003eBackground\u003c\/b\u003e\nGSK343 inhibits EZH2 and EZH1 histone-lysine N-methyltransferase activity through competitive inhibition of the cofactor S-Adenosyl-l-methionine (SAM). IC values for EZH2 and EZH1 are 4 nM and 60 nM, respectively (1). Research studies show that GSK343 displays more than 1000-fold selectivity relative to other methyltransferases (1,2). These studies demonstrate that GSK343 induces cancer cell autophagy and enhances the anti-cancer effects of the multi-kinase inhibitor, sorafenib (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nezh1; ezh2; h3k27; inhibitor; methylation; methyltransferase; sam cofactor","brand":"CST","offers":[{"title":"Default Title","offer_id":46800697360553,"sku":"66244S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-66244s","provider":"Iright","version":"1.0","type":"link"}