{"product_id":"cst-66849s","title":"CST,  66849S, NCOA4 (E8H8Z) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying NCOA4. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, NCOA4 (E8H8Z) Rabbit Monoclonal Antibody (CST #66849) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nNCOA4 (E8H8Z) Rabbit Monoclonal Antibody recognizes endogenous levels of total NCOA4 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly213 of human NCOA4 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nNuclear Receptor Coactivator 4 (NCOA4), also known as ARA70 or ELE1, was initially discovered as a transcriptional coactivator of androgen receptor (1,2). NCOA4 has also been implicated in regulation of peroxisome proliferator-activated receptor gamma and alpha, as well as estrogen receptor alpha (3-5). NCOA4 plays an autophagic role as a cargo receptor by shuttling ferritin to the lysosome in order to maintain iron homeostasis, which ultimately controls heme synthesis and red blood cell development (6-9). The gene has been shown to undergo a fusion event with the RET proto-oncogene, forming RET\/PTC3 in thyroid and other types of cancers (10-13).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n70 kDa androgen receptor coactivator; 70 kDa AR-activator; Androgen receptor coactivator 70 kDa protein; androgen receptor coactivator, 70-kD; Androgen receptor-associated protein of 70 kDa; ARA70; DKFZp762E1112; ELE1; NCoA-4; NCOA4; Nuclear receptor coactivator 4; papillary thyroid carcinoma 3; PTC3; ret fused; RET-activating gene ELE1; Ret-activating protein ELE1; RFG\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 80\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799846899881,"sku":"66849S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-66849s","provider":"Iright","version":"1.0","type":"link"}