{"product_id":"cst-67151t","title":"CST,  67151T, Integrin alpha-V (F3T8T) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying Integrin Alpha V. Validated for Western Blotting,Simple Western™,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, Integrin alpha-V (F3T8T) Rabbit Monoclonal Antibody (CST #67151) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nSimple Western™: 1:10 - 1:50\nImmunoprecipitation: 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nIntegrin alpha-V (F3T8T) Rabbit Monoclonal Antibody recognizes endogenous levels of total integrin alpha-V protein.\nSpecies Reactivity: Human, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human integrin alpha-V protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nIntegrins are α\/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 α and eight β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling) (1,2). Several αV subfamily members, including αVβ3, αVβ5, and αVβ1, are highly expressed in active endothelial cells and cancer cells (3-6), where they play a critical role in angiogenesis and tumor metastasis (7-9). Therefore, interest has focused on αV integrin as a key therapeutic target in cancer treatment (10-12).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nantigen identified by monoclonal antibody L230; CD51; DKFZp686A08142; Integrin alpha-V; Integrin alpha-V heavy chain; Integrin alpha-V light chain; integrin alphaVbeta3; integrin subunit alpha V; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); ITAV; ITGAV; MSK8; Vitronectin receptor; Vitronectin receptor subunit alpha; VNRA; VTNR\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H R\nSENSITIVITY: Endogenous\nMW (kDa): 140, 25\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799848505513,"sku":"67151T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-67151t","provider":"Iright","version":"1.0","type":"link"}