{"product_id":"cst-67380t","title":"CST,  67380T, Secernin-1 (F6Q7G) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying SCRN1. Validated for Western Blotting,Simple Western™,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, Secernin-1 (F6Q7G) Rabbit Monoclonal Antibody (CST #67380) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nSimple Western™: 1:10 - 1:50\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nSecernin-1 (F6Q7G) Rabbit Monoclonal Antibody recognizes endogenous levels of total secernin-1 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro335 of human secernin-1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nSecernin-1, encoded by the gene , is a 50 kDa cytosolic protein implicated in a variety of biological functions. Originally discovered as a protein that regulates mast cell exocytosis, secernin-1 has been suggested to play roles in axon growth, endoplasmic reticulum (ER) remodeling, and presynaptic vesicle recycling (1-3). In Alzheimer's disease (AD), secernin-1 was found to be abundant within amyloid plaques of dystrophic neurites and in neurofibrillary tangles (NFTs). Co-immunoprecipitation of secernin-1 and phosphorylated tau from AD patient brain samples further suggests a direct interaction between these proteins (4,5). Secernin-1 levels were also found to be increased in the cerebrospinal fluid (CSF) of AD patients, correlating with total and phospho-tau levels, suggesting its potential as a diagnostic and prognostic biofluid biomarker (6). Beyond AD, has been identified as a tumor-associated gene, with expression levels implicated in the development and progression of various cancers (7-9).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nKIAA0193; SCRN1; secernin 1; Secernin-1; SES1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 50\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799849357481,"sku":"67380T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-67380t","provider":"Iright","version":"1.0","type":"link"}