{"product_id":"cst-67499s","title":"CST,  67499S, CD103\/ITGAE (F2C7B) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CD103 mouse. Validated for Western Blotting,Immunohistochemistry (Paraffin),Immunofluorescence (Frozen). Available in 2 sizes. Highly specific and rigorously validated in-house, CD103\/ITGAE (F2C7B) Rabbit Monoclonal Antibody (CST #67499) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunohistochemistry (Paraffin): 1:200 - 1:800\nImmunofluorescence (Frozen): 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunohistochemistry (Paraffin), Immunofluorescence (Frozen)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCD103\/ITGAE (F2C7B) Rabbit Monoclonal Antibody recognizes endogenous levels of total CD103\/ITGAE protein. Nonspecific staining was observed in mouse kidney tubules, testis Leydig cells, and forestomach epithelium by immunohistochemistry.\nSpecies Reactivity: Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu152 of mouse CD103\/ITGAE protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCluster of differentiation molecule 103 (CD103)\/Integrin, alpha E (ITGAE) is a transmembrane protein forming heterodimers that are composed of α and β subunits. CD103\/ITGAE is expressed by subsets of CD4 and CD8 T cells, dendritic cells, and mast cells in mucosal tissues (1,2). The heterodimer composed of CD103\/ITGAE and integrin beta 7 interacts with E-cadherin, a cellular adhesion molecule found on epithelial cells. The CD103\/ITGAE and integrin beta 7 complex plays a role in thymocyte proliferation, intestinal T cell homing, and the antitumor immune response (3-5). Studies have shown that the presence of CD103\/ITGAE(+) immune cells can be used as markers for a favorable prognosis in different epithelial cancers (6,7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nA530055J10; alph; alpha-E1; alpha-M290; aM290; CD103; integrin alpha E, epithelial-associated; Integrin alpha M290; Integrin alpha-E; Integrin alpha-E heavy chain; Integrin alpha-E light chain; ITAE; Itgae; MGC183601; OTTMUSP00000006421; OTTMUSP00000006422\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M\nSENSITIVITY: Endogenous (IHC-P, IF-F), Transfected (W)\nMW (kDa): 130\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800110583977,"sku":"67499S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-67499s","provider":"Iright","version":"1.0","type":"link"}