{"product_id":"cst-67774t","title":"CST,  67774T, Ch-TOG (D2Z8J) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CKAP5. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Ch-TOG (D2Z8J) Rabbit Monoclonal Antibody (CST #67774) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCh-TOG (D2Z8J) Rabbit Monoclonal Antibody recognizes endogenous levels of total ch-TOG protein. Based on the amino acid sequence of the peptide antigen, this antibody is expected to recognize all isoforms of ch-TOG.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala31 of human ch-TOG protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCh-TOG (colonic hepatic tumor overexpressed gene)\/CKAP5 (cytoskeleton-associated protein 5) is a microtubule stabilizing protein involved in the organization of mitotic spindle poles through interaction with the transforming acid coiled-coil protein, TACC3 (1). Ch-TOG and TACC3 also interact with the membrane trafficking protein clathrin, and this interaction is thought to be required for clathrin's mitotic function in crosslinking microtubules in the mitotic spindle (2). Researchers have found that expression levels of both TACC3 and ch-TOG are correlated with human diseases such as glioblastoma and hepatic carcinoma (3). A genome-wide siRNA screen identified ch-TOG and other G2\/M phase regulators as potential contributors to head and neck squamous cell carcinoma (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCh-TOG; CHTOG; CKAP5; Colonic and hepatic tumor over-expressed gene protein; Colonic and hepatic tumor overexpressed gene protein; cytoskeleton associated protein 5; Cytoskeleton-associated protein 5; FLJ35359; KIAA0097; MSPS; TOG; TOGp; XMAP215\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 225\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799852535977,"sku":"67774T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-67774t","provider":"Iright","version":"1.0","type":"link"}