{"product_id":"cst-68966s","title":"CST,  68966S, Mouse IL-2 Recombinant Protein","description":"Growth Factors and Cytokines for studying IL2 mouse in the research area.\n\n\u003cb\u003eStorage\u003c\/b\u003e\nMouse IL-2 Recombinant Protein is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile 10 mM acetic acid at a concentration of 0.1 mg\/ml which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Once in solution, store at 4°C and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles if storing reconstituted material at -20ºC to -80ºC.\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nRecombinant mouse IL-2 was expressed in and is supplied in a lyophilized form.\n\u003cb\u003eBackground\u003c\/b\u003e\nInterleukin-2 (IL-2) is a T cell stimulatory cytokine best known for inducing T cell proliferation and NK cell proliferation and activation (1,2). IL-2 also promotes peripheral development of regulatory T cells (Tregs) (3,4). Conversely, IL-2 is involved in the activation-induced cell death (AICD) that is observed post T cell expansion by increasing levels of Fas on CD4 T cells (5). The effects of IL-2 are mediated through a trimeric receptor complex consisting of IL-2Rα, IL-2Rβ, and the common gamma chain, γc (1,2). IL-2Rα binds exclusively to IL-2 with low affinity and increases the binding affinity of the whole receptor complex including IL-2Rβ and γc subunits. IL-15 also binds to IL-2Rβ (1,2). γc is used by other cytokines, including IL-4, IL-7, IL-9, IL-15, and IL-21 (1,2). Binding of IL-2 initiates signaling cascades involving Jak1, Jak3, Stat5, and the PI3K\/Akt pathways (1,2).","brand":"CST","offers":[{"title":"Default Title","offer_id":46800716005545,"sku":"68966S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-68966s","provider":"Iright","version":"1.0","type":"link"}