{"product_id":"cst-68998s","title":"CST,  68998S, U-18666A","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nU-18666A is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.17 ml of water. Working concentrations and length of treatment can vary depending on the desired effect.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles.\n\u003cb\u003eBackground\u003c\/b\u003e\nU-18666A is a cell permeable drug that inhibits cholesterol transport. This small molecule inhibits low density lipoprotein (LDL)-derived cholesterol transport, blocking cholesterol esterification, and suppressing LDL receptor activities (1). Studies have shown that impaired cholesterol trafficking is associated with neurological diseases such as Alzheimer's disease (AD), Niemann-Pick disease type C (NPC), and atherosclerosis (2,3). The mechanisms of neurodegeneration for these diseases are mostly unknown so studies using U-18666A to simulate intracellular cholesterol accumulation may provide greater insight into these pathologies (2). Cholesterol levels play a role in the body's response to viral infection and the ability of a virus to enter and replicate within a host cell, making U-18666A an important compound when studying different viral diseases (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n(3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one, hydrochloride; U-18666A hydrochloride; U18666A; U18666A hydrochloride","brand":"CST","offers":[{"title":"Default Title","offer_id":46800697622697,"sku":"68998S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-68998s","provider":"Iright","version":"1.0","type":"link"}