{"product_id":"cst-6922s","title":"CST,  6922S, ACO2 Antibody","description":"Polyclonal Antibody for studying ACO2. Validated for Western Blotting,Immunofluorescence (Immunocytochemistry). Highly specific and rigorously validated in-house, ACO2 Antibody (CST #6922) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunofluorescence (Immunocytochemistry): 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunofluorescence (Immunocytochemistry)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nACO2 Antibody recognizes endogenous levels of total ACO2 protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly540 of human ACO2 protein. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nAconitase 2 (ACO2) catalyzes the conversion of citrate to isocitrate via cis-aconitate in the second step of the tricarboxylic acid (TCA) cycle (1,2). ACO2 is also an important regulator of iron homeostasis within cells (1-4). In addition, research studies have shown that this enzyme is deficient in the mitochondrial disease Friedreich's Ataxia (4,5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nACO2; ACON; Aconitase; aconitase 2; aconitase 2, mitochondrial; Aconitate hydratase, mitochondrial; ACONM; Citrate hydro-lyase; epididymis secretory sperm binding protein Li 284; HEL-S-284; ICRD; MGC20605; MGC33908; mitochondrial aconitase; OCA8; OPA9\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 85\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799859515561,"sku":"6922S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-6922s","provider":"Iright","version":"1.0","type":"link"}