{"product_id":"cst-69387s","title":"CST,  69387S, MAP4K3 (E9L1J) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying MAP4K3 mouse. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, MAP4K3 (E9L1J) Rabbit Monoclonal Antibody (CST #69387) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMAP4K3 (E9L1J) Rabbit Monoclonal Antibody recognizes endogenous levels of total MAP4K3 protein. A band of unknown identity is detected at 48 kDa.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding His404 of human MAP4K3 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe mTORC1 kinase complex is a critical regulator of cell growth (1,2). Its activity is modulated by growth factors and nutrients including amino acids (1,2). MAP4K3 is a mediator between nutrient signal and mTORC1 (1). Research studies suggest that amino acid sufficiency leads to the phosphorylation of Ser170 on MAP4K3, which activates mTORC1 (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n4833416M01Rik; 4833416M07Rik; 9530052P13Rik; germinal center kinase-like kinase-like; Germinal center kinase-related protein kinase; GLK; KHS2; M4K3; Map4k3; MAPK\/ERK kinase kinase kinase 3; MAPKKKK3; MEK kinase kinase 3; MEKKK 3; MEKKK3; mitogen activated protein kinase kinase kinase kinase 3; Mitogen-activated protein kinase kinase kinase kinase 3; RAB8IPL1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 101\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799860531369,"sku":"69387S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-69387s","provider":"Iright","version":"1.0","type":"link"}