{"product_id":"cst-69569s","title":"CST,  69569S, ANT1\/SLC25A4 Antibody","description":"Polyclonal Antibody for studying SLC25A4\/ANT1. Validated for Western Blotting. Highly specific and rigorously validated in-house, ANT1\/SLC25A4 Antibody (CST #69569) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nANT1\/SLC25A4 Antibody recognizes endogenous levels of total ANT1\/SLC25A4 protein. This antibody does not cross-react with ANT2\/SLC25A5 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala150 of human ANT1\/SLC25A4 protein. Antibodies are purified by peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nAdenine nucleotide translocators (ANTs) are a family of mitochondrial proteins that exchange ATP and ADP across the mitochondrial inner membrane. ANT1, also known as solute carrier family 25 member 4 (SLC25A4), is the isoform predominantly expressed in heart, muscle, and brain (1,2). Homozygous loss-of-function mutations in causes cardiomyopathy (2,3). In addition, ANT1\/SLC25A4 is shown to be required for mitophagy (3). Furthermore, research studies show that ANT1\/SLC25A4 facilitates mitochondrial permeability transition induced by bile acids and, therefore, pyroptosis (4). ANT1\/SLC25A4 may mediate the release of ATP from mitochondria to the cytoplasm in this process, which is critical for pyroptosome assembly (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAAC1; Adenine nucleotide translocator 1; adenine nucleotide translocator 1 (skeletal muscle); adenine nucleotide translocator), member 4; ADP,ATP carrier protein 1; ADP,ATP carrier protein, heart\/skeletal muscle; ADP,ATP carrier protein, heart\/skeletal muscle isoform T1; ADP\/ATP translocase 1; ADT1; ANT; ANT 1; ANT1; heart\/skeletal muscle ATP\/ADP translocator; MTDPS12; MTDPS12A; PEO2; PEO3; PEOA2; SLC25A4; solute carrier family 25 (mitochondrial carrier; Solute carrier family 25 member 4; T1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 28\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799862759593,"sku":"69569S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-69569s","provider":"Iright","version":"1.0","type":"link"}