{"product_id":"cst-69721t","title":"CST,  69721T, YKL-40 (F9N3K) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CHI3L1 mouse. Validated for Immunoprecipitation,Immunofluorescence (Frozen). Available in 2 sizes. Highly specific and rigorously validated in-house, YKL-40 (F9N3K) Rabbit Monoclonal Antibody (CST #69721) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nImmunoprecipitation: 1:100\nImmunofluorescence (Frozen): 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Immunoprecipitation, Immunofluorescence (Frozen)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nYKL-40 (F9N3K) Rabbit mAb recognizes endogenous levels of total YKL-40 protein.\nSpecies Reactivity: Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of mouse YKL-40 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nYKL-40, also known as chitinase-3-like protein 1 (CHI3L1), is a secreted glycoprotein encoded by the gene (1,2). Unlike other members of the chitinase-like protein family, YKL-40 is not an active chitinase. It is produced by activated macrophages, chondrocytes, neutrophils, and synovial cells. It is a pro-inflammatory molecule that contributes to the progression of many inflammatory diseases, including fibrosis, neurodegenerative disease, breast, lung, prostate, liver, bladder, colon, and other types of cancers (3,4). Levels of YKL-40 in serum and plasma in patients with various types of tumors have been reported to predict poor prognosis, and in some clinical assays, YKL-40 is being used as a predictive biomarker of cancer outcome (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAW208766; Breast regression protein 39; Brp; Brp39; BRP39 protein; Cartilage glycoprotein 39; CGP-39; CH3L1; Chi3; Chi3l1; Chil1; chitinase 3 like 1; chitinase 3-like 1; Chitinase-3-like protein 1; chitinase-like 1; GP-39; Gp3; Gp39\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M\nSENSITIVITY: Endogenous\nMW (kDa): 44\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800248406185,"sku":"69721T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-69721t","provider":"Iright","version":"1.0","type":"link"}