{"product_id":"cst-69857s","title":"CST,  69857S, Niclosamide","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nNiclosamide is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.02 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles.\n\u003cb\u003eBackground\u003c\/b\u003e\nNiclosamide is a STAT3 inhibitor (IC = 0.25 μM) known to induce apoptosis and cell cycle arrest (1). This small molecule stimulates autophagy by reversibly inhibiting mammalian target of rapamycin complex 1 (mTORC1) signaling and inhibiting phosphorylation of ribosomal S6 kinases at certain concentrations (2). In clinical settings, Niclosamide has been used to treat parasitic-driven diseases in humans as an antihelminthic drug. Studies have shown Niclosamide to be an effective antiviral agent, inhibiting the replication of SARS-CoV (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide","brand":"CST","offers":[{"title":"Default Title","offer_id":46800697852073,"sku":"69857S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-69857s","provider":"Iright","version":"1.0","type":"link"}