{"product_id":"cst-6988t","title":"CST,  6988T, MAML2 (D41E6) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying MAML2. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, MAML2 (D41E6) Rabbit Monoclonal Antibody (CST #6988) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMAML2 (D41E6) Rabbit Monoclonal Antibody detects endogenous levels of total MAML2 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp800 of human MAML2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nMastermind-like (MAML) family of proteins are homologs of Mastermind. The family is composed of three members in mammals: MAML1, MAML2, and MAML3 (1,2). MAML proteins form complexes with the intracellular domain of Notch (ICN) and the transcription factor CSL (RBP-Jκ) to regulate Notch target gene expression (3-5). MAML1 also interacts with myocyte enhancer factor 2C (MEF2C) to regulate myogenesis (6). MAML2 is frequently found to be fused with Mucoepidermoid carcinoma translocated gene 1 (MECT1, also know as WAMTP1 or TORC1) in patients with mucoepidermoid carcinomas and Warthin's tumors (7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nDKFZp686N0150; KIAA1819; Mam-2; MAM-3; MAM2; MAM3; MAML2; mastermind like transcriptional coactivator 2; mastermind-like 2; mastermind-like 2 (Drosophila); Mastermind-like protein 2; MGC176701; MLL-MAML2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 160\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799864889513,"sku":"6988T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-6988t","provider":"Iright","version":"1.0","type":"link"}