{"product_id":"cst-6996t","title":"CST,  6996T, RAGE 1 (D1A12) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying RAGE. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, RAGE 1 (D1A12) Rabbit Monoclonal Antibody (CST #6996) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nRAGE 1 (D1A12) Rabbit Monoclonal Antibody recognizes endogenous levels of total RAGE 1 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human RAGE 1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin (Ig) superfamily. It can be expressed as full-length, membrane-bound RAGE isoform 1 or as a secreted sRAGE protein that lacks a transmembrane domain (1). RAGE is detected during early developmental stages and in the lung under normal physiological conditions (2), and it is upregulated at sites of inflammation (3). Advanced glycation end products (AGEs) and a variety of other ligands interact with this receptor (1). Ligand binding activates full-length RAGE and initiates downstream signaling pathways that include activation of NF-κB, which leads to production of pro-inflammatory cytokines and inflammation (4). Activation of these pathways has been implicated in various disease states including Alzheimer's disease, diabetes, arthritis, and atherosclerosis (4). Soluble RAGE can competitively bind RAGE ligands in the extracellular environment, which prevents ligand interaction with full-length RAGE at the cell surface (1).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAdvanced glycosylation end product-specific receptor; advanced glycosylation end-product specific receptor; AGER; MGC22357; RAGE; receptor for advanced glycation end-products variant 20; receptor for advanced glycosylation end products; receptor for advanced glycosylation end-products; SCARJ1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 55\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799865675945,"sku":"6996T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-6996t","provider":"Iright","version":"1.0","type":"link"}