{"product_id":"cst-70372s","title":"CST,  70372S, dUTPase\/DUT (F3X6Z) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying dUTPase\/DUT. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, dUTPase\/DUT (F3X6Z) Rabbit Monoclonal Antibody (CST #70372) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\ndUTPase\/DUT (F3X6Z) Rabbit Monoclonal Antibody recognizes endogenous levels of total dUTPase\/DUT protein.\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val188 of human dUTPase\/DUT protein.\n\u003cb\u003eBackground\u003c\/b\u003e\ndUTP pyrophosphatase (dUTPase), also known as deoxyuridine triphosphatase (DUT), catalyzes the conversion of dUTP to dUMP and pyrophosphate (1,2). Studies show that fumarate, an intermediate in the TCA\/Krebs cycle, functions as a signaling metabolite to regulate mitochondrial biogenesis. Fumarate binds to the mitochondrial enzyme, malic enzyme 2 (ME2), and stimulates the formation of ME2 dimers. ME2 dimers, in turn, activate the enzymatic activity of dUTPase\/DUT, promoting thymidine biosynthesis and increasing mitochondrial DNA replication (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial; deoxyuridine triphosphatase; DUT; dUTP diphosphatase; dUTP nucleotidohydrolase; dUTP pyrophosphatase; dUTPase; FLJ20622\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M\nSENSITIVITY: Endogenous\nMW (kDa): 20\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799867740329,"sku":"70372S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-70372s","provider":"Iright","version":"1.0","type":"link"}