{"product_id":"cst-70976s","title":"CST,  70976S, Human Anti-CD3\/CD28 T Cell Activation Kit","description":"Assay Kit for studying in the research area.\n\n\u003cb\u003eStorage\u003c\/b\u003e\nAll components in this kit are stable for 12 months when stored at the recommended temperature.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Functional\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nThe Human Anti-CD3\/CD28 T Cell Activation Kit is used for the stimulation of human T cells following the soluble stimulation protocol.\n\u003cb\u003eBackground\u003c\/b\u003e\nT cells are activated by signaling through ITAM (immunoreceptor tyrosine-based activation motif)-containing CD3 signaling chains that associate with the T cell receptor (1). Co-stimulation through CD28 on T cells provides an additional signal required for effective T cell activation (2). Signaling through both CD3 and CD28 can be initiated using the agonist antibodies Human CD3ε Activating (OKT3) Mouse mAb (Low Endotoxin, Azide-free) and Human CD28 Activating (CD28.2) Mouse mAb (Low Endotoxin, Azide-free), respectively. If the agonist antibodies are used in the soluble stimulation protocol, cross-linking of their Fc domains using Goat Anti-Mouse Kappa Light Chain, F(ab') Antibody (Low Endotoxin, Azide-free) is required for optimal stimulation.","brand":"CST","offers":[{"title":"Default Title","offer_id":46800802381993,"sku":"70976S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-70976s","provider":"Iright","version":"1.0","type":"link"}