{"product_id":"cst-71590s","title":"CST,  71590S, RNF128 Antibody","description":"Polyclonal Antibody for studying RNF128. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, RNF128 Antibody (CST #71590) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nRNF128 Antibody recognizes endogenous levels of total RNF128 protein. This antibody detects a 40 kDa band of unknown origin in some cell lines.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human RNF128 protein. Antibodies are purified by peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nRNF128, also known as gene related to anergy in lymphocytes (GRAIL), is a RING finger protein family E3 ubiquitin ligase that participates in T cell anergy induction (1,2). RNF128 is a type I transmembrane protein, made up of a zinc RING finger, coiled-coil, and protease-associated domain (1,2). Expression of RNF128\/GRAIL has been shown to inhibit cytokine transcription and CD4 T cell proliferation, as well as regulate naïve T cell tolerance induction and Treg cell function (2-4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nE3 ubiquitin-protein ligase RNF128; FLJ23516; Gene related to anergy in lymphocytes protein; GRAIL; RING finger protein 128; ring finger protein 128, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase RNF128; RN128; RNF128\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 60-80\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799874490537,"sku":"71590S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-71590s","provider":"Iright","version":"1.0","type":"link"}