{"product_id":"cst-71812s","title":"CST,  71812S, TMEM115 (F6N4Y) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying TMEM115. Validated for Western Blotting,Simple Western™,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, TMEM115 (F6N4Y) Rabbit Monoclonal Antibody (CST #71812) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nThis product was developed by CST ® scientists in collaboration with The Michael J. Fox Foundation (MJFF). Our partnership aims to accelerate Parkinson's disease (PD) research by identifying and developing high-quality monoclonal antibodies for promising PD targets. Visit the CST Parkinson's Disease Resource Center to learn more: https:\/\/cst-science.com\/PD-Resources .\nWestern Blotting: 1:1000\nSimple Western™: 1:10 - 1:50\nImmunoprecipitation: 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nTMEM115 (F6N4Y) Rabbit Monoclonal Antibody recognizes endogenous levels of total TMEM115 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp325 of human TMEM115 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nTransmembrane protein 115 (TMEM115) is a 35 kDa protein localized to the Golgi cisternae. Both the N- and C-terminal ends of TMEM115 are oriented toward the cytosol, with four transmembrane domains and a Golgi targeting sequence located in between. While the functions of this protein are not fully understood, it is suggested to play roles in Golgi-to-ER retrograde transport and glycosylation (1). Elevated TMEM115 expression levels have been observed in glioma and hepatocellular carcinoma, indicating its potential as a biomarker and therapeutic target for these cancers (2,3). Golgi dysfunction is associated with many diseases, including cancer, neurodegeneration, and cardiovascular diseases. As a Golgi-specific transmembrane protein, TMEM115 can be leveraged for immunoprecipitation experiments to purify and study the Golgi proteome, metabolome, and lipidome in health and disease (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nPL6; Placental protein 6; PP6; Protein PL6; testicular tissue protein Li 201; TM115; TMEM115; Transmembrane protein 115\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 35\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799875408041,"sku":"71812S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-71812s","provider":"Iright","version":"1.0","type":"link"}