{"product_id":"cst-71888t","title":"CST,  71888T, NCR1\/NKp46 (F8M2L) Rabbit Monoclonal Antibody (IHC Formulated)","description":"Monoclonal Antibody for studying NCR1 mouse. Validated for Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, NCR1\/NKp46 (F8M2L) Rabbit Monoclonal Antibody (IHC Formulated) (CST #71888) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nImmunohistochemistry (Paraffin): 1:25 - 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nNCR1\/NKp46 (F8M2L) Rabbit Monoclonal Antibody (IHC Formulated) recognizes endogenous levels of total NCR1\/NKp46 protein.\nSpecies Reactivity: Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of mouse NCR1\/NKp46 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe family of natural cytotoxicity receptors (NCRs) contains NCR1 (NKp46\/CD335), NCR2 (NKp44\/CD336), and NCR3 (NKp30\/CD337). They are single-pass type I transmembrane proteins belonging to the immunoglobulin (Ig) superfamily. Various pathogen-derived and host-encoded molecules have been identified as ligands for the NCRs. They were originally identified by their ability to evoke the cytotoxicity of natural killer (NK) cells toward tumor cells , and animal models have demonstrated that NCRs play a role in tumor surveillance, viral infection, and pregnancy (1-5). NCR1\/NKp46 is considered a universal marker for NK cells, and recent studies found that it is also expressed by other cells, such as group 1 innate lymphoid cells (ILC1s), a subset of group 3 ILCs (NCR+ ILC3), and γδ T cells (2-4). NCR1\/NKp46 is also expressed on and considered a diagnostic marker and therapeutic target for some malignant NK, NKT, and T cell lymphomas (6,7). Cross-linking NCR1\/NKp46 with antibodies can activate NK cells, which has been pursued as a promising therapeutic avenue (8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nActivating receptor 1; CD335; Ly9; Ly94; Lymphocyte antigen 94; mAR-1; MAR1 (mouse activating receptor 1); mNKp46; Natural cytotoxicity triggering receptor 1; Natural killer cell p46-related protein; NCR1; NCTR1; NK-p46; NKp; NKp46\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M\nSENSITIVITY: Endogenous\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800286056617,"sku":"71888T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-71888t","provider":"Iright","version":"1.0","type":"link"}