{"product_id":"cst-72040v4","title":"CST,  72040V4, PathScan® Phospho-Axl (Tyr702) Sandwich ELISA Kit","description":"ELISA Kit for studying Axl (Tyr702) phosphate in the research area.\n\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: ELISA+\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nThe PathScan\nSpecies Reactivity: Human\n\u003cb\u003eBackground\u003c\/b\u003e\nAxl, Sky, and Mer are three members of a receptor tyrosine kinase (RTK) family that share a conserved intracellular tyrosine kinase domain and an extracellular domain similar to those seen in cell adhesion molecules. These RTKs bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6), which is structurally related to the protein S anticoagulation factor (1). Upon binding to its receptor, Gas6 activates phosphatidylinositol 3-kinase (PI3K) and its downstream targets Akt and S6K, as well as NF-κB (2,3). A large body of evidence supports a role for Gas6\/Axl signaling in cell growth and survival in normal and cancer cells (4). Phosphorylation of Axl receptor on Tyr702 was identified at Cell Signaling Technology (CST) using PTMScan , CST's LC-MS\/MS platform for modified site discovery (5). Phosphorylation of Axl on Tyr702 was also reported in select carcinoma cell lines (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nARK; AXL; AXL oncogene; AXL receptor tyrosine kinase; AXL transforming sequence\/gene; JTK11; oncogene AXL; Tyro7; Tyrosine-protein kinase receptor UFO; UFO\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H","brand":"CST","offers":[{"title":"Default Title","offer_id":46800639787177,"sku":"72040V4","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-72040v4","provider":"Iright","version":"1.0","type":"link"}