{"product_id":"cst-7287c","title":"CST,  7287C, PathScan® Phospho-IRS-1 (Ser307) Sandwich ELISA Kit","description":"ELISA Kit for studying IRS-1 (Ser312) phosphate in the research area.\n\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: ELISA+\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPathScan\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eBackground\u003c\/b\u003e\nInsulin receptor substrate 1 (IRS-1) is one of the major substrates of the insulin receptor kinase (1). IRS-1 contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain containing proteins that mediate the metabolic and growth-promoting functions of insulin (2-4). IRS-1 also contains over 30 potential serine\/threonine phosphorylation sites. Ser307 of IRS-1 is phosphorylated by JNK (5) and IKK (6) while Ser789 is phosphorylated by SIK-2, a member of the AMPK family (7). The PKC and mTOR pathways mediate phosphorylation of IRS-1 at Ser612 and Ser636\/639, respectively (8,9). Phosphorylation of IRS-1 at Ser1101 is mediated by PKCθ and results in an inhibition of insulin signaling in the cell, suggesting a potential mechanism for insulin resistance in some models of obesity (10).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nHIRS-1; Insulin receptor substrate 1; IRS-1; IRS1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M","brand":"CST","offers":[{"title":"Default Title","offer_id":46800649420969,"sku":"7287C","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-7287c","provider":"Iright","version":"1.0","type":"link"}