{"product_id":"cst-72908s","title":"CST,  72908S, PEAK1 (D4G6J) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying PEAK1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, PEAK1 (D4G6J) Rabbit Monoclonal Antibody (CST #72908) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPEAK1 (D4G6J) Rabbit Monoclonal Antibody recognizes endogenous levels of total PEAK1 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Thr695 of human PEAK1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nPEAK1 (Pseudopodium-enriched atypical kinase 1 or sgk269) is a member of nonreceptor atypical tyrosine kinase family identified by MS analysis of purified psedopodium (1). PEAK1 is a multi-domain protein with a N-terminal Erk binding site, followed by actin-targeting\/Src substrate\/Erk substrate region, Crk binding site, Shc binding site, and a C-terminal kinase domain (1, 2). By interacting with different adaptors like Shc, Grb2, Src, and others, PEAK1 functions as an important regulator in different signaling pathways, namely the Src\/PEAK1\/ErbB2 (3), EGFR Shc1\/PEAK1\/Grb2(4), TGFβ\/PEAK1\/Src\/MAPK (5), and fibronectin\/PEAK1\/Src (6) pathways. PEAK1 plays an instrumental role in a wide variety of biological processes including epithelial-mesenchymal transition (EMT), dynamics of focal adhesion, cancer metastatic growth and invasion as well as cancer drug resistance (3, 5-8). Phosphorylation of PEAK1 at Tyr665 or Tyr635 by SFK (Src family Kinases) has been shown to be essential for cancer cell migration and invasion as well as the turnover of focal adhesions (7, 9).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nFLJ21140; FLJ34483; Inactive tyrosine-protein kinase PEAK1; KIAA2002; NKF3 kinase family member; PEAK1; pseudopodium enriched atypical kinase 1; Pseudopodium-enriched atypical kinase 1; SG269; SGK269; Sugen kinase 269; Tyrosine-protein kinase SgK269\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 250\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799879930025,"sku":"72908S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-72908s","provider":"Iright","version":"1.0","type":"link"}