{"product_id":"cst-73663t","title":"CST,  73663T, Integrin beta2 (D4N5Z) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying Integrin Beta2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Integrin beta2 (D4N5Z) Rabbit Monoclonal Antibody (CST #73663) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nIntegrin beta2 (D4N5Z) Rabbit Monoclonal Antibody recognizes endogenous levels of total Integrin β2 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu49 of human Integrin β2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nIntegrins are transmembrane glycoproteins that form heterodimers consisting of one α and one β subunit. Integrin dimers act as receptors for extracellular matrix proteins and cell-surface ligands. Integrin signaling to (inside-out) and from (outside-in) extracellular molecules regulates multiple cellular processes, such as development, wound healing, immune response, invasion, metastasis, and angiogenesis (1,2). Integrin β2 (CD18) is the β subunit of the leukocyte-specific integrin family. Leukocyte integrins include Integrin β2 (CD18)\/αL (CD11a) (LFA-1, lymphocyte function associated antigen 1), Integrin β2 (CD18)\/αM (CD11b) (Mac-1), Integrin β2 (CD18)\/αX (CD11c), and Integrin β2 (CD18)\/αD (CD11d). These integrins bind to immunoglobulin superfamily members, such as ICAM-1 and VCAM-1 on endothelial cells, to mediate firm adhesion and transendothelial migration of leukocytes (3). Integrin β2 (CD18) deficiency results in LAD (leukocyte adhesion deficiency), a disease characterized by impairment of leukocyte recruitment, resulting in an inability to fight infection (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCD18; cell surface adhesion glycoprotein (LFA-1\/CR3\/P150,959 beta subunit precursor); cell surface adhesion glycoprotein LFA-1\/CR3\/P150,959 beta subunit precursor); Cell surface adhesion glycoproteins LFA-1\/CR3\/p150,95 subunit beta; complement component 3 receptor 3 and 4 subunit; complement receptor C3 beta-subunit; Complement receptor C3 subunit beta; integrin beta chain, beta 2; Integrin beta-2; integrin subunit beta 2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); ITB2; ITGB2; LAD; LCAMB; leukocyte cell adhesion molecule CD18; leukocyte-associated antigens CD18\/11A, CD18\/11B, CD18\/11C; LFA-1; MAC-1; MF17; MFI7; truncated integrin beta-2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 95\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799884189865,"sku":"73663T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-73663t","provider":"Iright","version":"1.0","type":"link"}