{"product_id":"cst-73671s","title":"CST,  73671S, IFN-beta1 (D1D7G) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying IFN-beta1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, IFN-beta1 (D1D7G) Rabbit Monoclonal Antibody (CST #73671) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nIFN-beta1 (D1D7G) Rabbit Monoclonal Antibody recognizes endogenous levels of total IFN-β1 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant human IFN-β1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe type I interferon (IFN) family includes IFN-β1 and IFN-α1 through IFN-α13 in humans and IFN-α1 through IFN-α14 in mice. Type I IFN is produced following detection of pathogen-associated molecular patterns (PAMPs) and is important for induction of antiviral genes, activation of dendritic cells, and initiation of adaptive immunity (1, 2). Type I IFNs signal through the IFN alpha receptor (IFNAR), which is a heterodimer composed of IFNAR1 and IFNAR2. Activation of IFNAR leads to formation of the nuclear complex IFN-stimulated gene factor 3 (ISGF3), which consists of STAT1, STAT2, and IRF-9 (3, 4). ISGF3 binds to IFN-stimulated response elements (ISREs) to initiate transcription of interferon-stimulated genes (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nFibroblast interferon; IFB; IFF; IFN-beta; IFNB; IFNB1; Interferon beta; interferon beta 1; interferon-beta; interferon, beta 1, fibroblast; MGC96956\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 19, 21\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799884288169,"sku":"73671S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-73671s","provider":"Iright","version":"1.0","type":"link"}