{"product_id":"cst-73951t","title":"CST,  73951T, NDUFB8 (E7U3O) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying NDUFB8. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, NDUFB8 (E7U3O) Rabbit Monoclonal Antibody (CST #73951) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nNDUFB8 (E7U3O) Rabbit Monoclonal Antibody recognizes endogenous levels of total NDUFB8 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly171 of human NDUFB8 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nNADH:ubiquinone oxidoreductase (complex I) is a large protein complex in the mitochondrial respiratory chain with multiple subunits. Complex I catalyzes the transfer of electrons from NADH to ubiquinone. NDUFB8 is one of the accessory subunits of mitochondrial complex I and is essential for its assembly (1). Studies show that nitration of NDUFB8 leads to necrosis mediated by RIP1 and RIP3 (2). In addition, variants cause deficiency of mitochondrial complex I in patients with Leigh-like encephalomyopathy (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nASHI; CI-ASHI; complex I ASHI subunit; Complex I-ASHI; MC1DN32; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; NADH-ubiquinone oxidoreductase ASHI subunit; NADH:ubiquinone oxidoreductase ASHI subunit; NADH:ubiquinone oxidoreductase subunit B8; NDUB8; NDUFB8\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 19\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799885336745,"sku":"73951T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-73951t","provider":"Iright","version":"1.0","type":"link"}