{"product_id":"cst-73989s","title":"CST,  73989S, MPEG1 (F1S7U) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying MPEG1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, MPEG1 (F1S7U) Rabbit Monoclonal Antibody (CST #73989) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMPEG1 (F1S7U) Rabbit Monoclonal Antibody recognizes endogenous levels of total MPEG1 protein. This antibody detects a 28 kDa and an 180 kDa protein of unknown identity in some cell lines.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly550 of human MPEG1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nMacrophage-expressed gene 1 protein (MPEG1), also known as perforin-2, is a member of the Membrane Attack Complex\/Perforin (MACPF) superfamily of pore-forming proteins (1,4). MPEG1, mainly expressed in macrophages and leukocytes, can be upregulated in response to proinflammatory signals such as tumor necrosis factor α (TNF-α) and lipopolysaccharides (LPS) (1-3). MPEG1 is involved in both innate and adaptive immunity, localizing to early endosomes and phagosomes\/lysosomes, and acts in an antimicrobial capacity (4). In dendritic cells, MPEG1 helps deliver antigens into the cytosol, where they can be processed and presented on MHC class I molecules to activate CD8 T cells (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nlikely ortholog of mouse macrophage expressed gene 1; macrophage expressed 1; macrophage expressed gene 1; Macrophage gene 1 protein; Macrophage-expressed gene 1 protein; MGC132657; MGC138435; MPEG1; Mpg-1; MPG1; MPS1; P-2; partial protein; perforin 2; Perforin-2; Q2M385\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 80-100\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799885631657,"sku":"73989S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-73989s","provider":"Iright","version":"1.0","type":"link"}