{"product_id":"cst-74054s","title":"CST,  74054S, Necrosulfonamide","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nNecrosulfonamide is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.08 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles.\n\u003cb\u003eBackground\u003c\/b\u003e\nNecrosulfonamide is a potent, selective necroptosis inhibitor with an IC value of less than 0.2 µM. It inhibits mixed lineage kinase domain-like protein (MLKL), and blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. Necrosulfonamide has been shown to effectively prevent the MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors (1).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n(2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2- propenamide","brand":"CST","offers":[{"title":"Default Title","offer_id":46800698081449,"sku":"74054S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-74054s","provider":"Iright","version":"1.0","type":"link"}