{"product_id":"cst-74748t","title":"CST,  74748T, Kv4.2 (D3E7G) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying Kv4.2. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, Kv4.2 (D3E7G) Rabbit Monoclonal Antibody (CST #74748) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nKv4.2 (D3E7G) Rabbit Monoclonal Antibody recognizes endogenous levels of total Kv4.2 protein. This antibody does not cross-react with Kv4.1 and Kv4.3 proteins.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human Kv4.2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nKv4.2 is a voltage-gated potassium channel that belongs to the Shal-related subfamily. Kv4.2 mediates K+ transport in excitable membranes primarily in the brain, where it regulates neuronal excitability, synaptic plasticity, and the circadian rhythm of locomotor activity (1-6). In rodent heart, Kv4.2 mediates the transient outward current (Ito), which contributes to early repolarization and the cardiac action potential (7). Kv4.2 can form homotetramers or heterotetramers with other members of the Shal-related subfamily. Interaction with modulating β subunits such as KChIP family proteins modulates Kv4.2 expression at cell surface and its channel activity (8-10).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nKCND2; KIAA1044; KV4.2; MGC119702; MGC119703; potassium channel, voltage gated Shal related subfamily D, member 2; Potassium voltage-gated channel subfamily D member 2; potassium voltage-gated channel, Shal-related subfamily, member 2; RK5; voltage-gated potassium channel Kv4.2; Voltage-gated potassium channel subunit Kv4.2; voltage-sensitive potassium channel\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 70\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799889072297,"sku":"74748T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-74748t","provider":"Iright","version":"1.0","type":"link"}