{"product_id":"cst-74981s","title":"CST,  74981S, MB21D2 Antibody","description":"Polyclonal Antibody for studying MB21D2. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, MB21D2 Antibody (CST #74981) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMB21D2 Antibody recognizes endogenous levels of total MB21D2 protein. This antibody detects a 180 kDa band of unknown origin.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MB21D2 protein. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nMab-21 domain-containing protein 2 (MB21D2), also known as C3orf59, belongs to a protein family of cGAS\/DncV-like nucleotidyltransferase (CD-NTase) enzymes involved in a variety of cellular processes, including cell survival, proliferation, and migration (3). MB21D2 is an intracellular E-cadherin binder that carries a recurrent mutation (1,4). Both wild-type (WT) and mutant have been identified as being frequently overexpressed in lung, head, and neck cancers, and may mediate pro-oncogenic activities by promoting epithelial-mesenchymal transition (EMT)\/cancer stemness (2-4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nC3orf59; CC059; chromosome 3 open reading frame 59; hypothetical protein LOC151963; M21D2; Mab-21 domain containing 2; Mab-21 domain-containing protein 2; MB21D2; Nucleotidyltransferase MB21D2; Protein MB21D2; Uncharacterized protein C3orf59\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 56\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799890088105,"sku":"74981S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-74981s","provider":"Iright","version":"1.0","type":"link"}