{"product_id":"cst-75073s","title":"CST,  75073S, A 83-01","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nA 83-01 is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.18 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 2 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles.\n\u003cb\u003eBackground\u003c\/b\u003e\nA 83-01 is a potent and selective inhibitor of TGF-β type I receptor ALK5 kinase, activin type IB receptor ALK4, and nodal type I receptor ALK7 with an IC value of 12, 45, and 7.5 nM, respectively (1). This small molecule has also been shown to inhibit Smad2\/3 phosphorylation along with TGF-β-induced growth inhibition and induction of Twist and Wnt3 (1,2). A 83-01 can be used to stabilize rat induced pluripotent stem cell (riPSC) cultures by inhibiting spontaneous differentiation and increasing the clonal expansion efficiency (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide; A-83-01; A83-01","brand":"CST","offers":[{"title":"Default Title","offer_id":46800698146985,"sku":"75073S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-75073s","provider":"Iright","version":"1.0","type":"link"}