{"product_id":"cst-75181t","title":"CST,  75181T, CD14 (D7A2T) Rabbit Monoclonal Antibody (IHC Formulated)","description":"Monoclonal Antibody for studying CD14. Validated for IHC Leica Bond,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, CD14 (D7A2T) Rabbit Monoclonal Antibody (IHC Formulated) (CST #75181) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nIHC Leica Bond: 1:200\nImmunohistochemistry (Paraffin): 1:500\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 43878 .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: IHC Leica Bond, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCD14 (D7A2T) Rabbit Monoclonal Antibody (IHC Formulated) recognizes endogenous levels of total CD14 protein.\nSpecies Reactivity: Human, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro319 of human CD14 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCD14 is a leucine-rich repeat-containing pattern recognition receptor with expression largely restricted to the monocyte\/macrophage cell lineage (1). Research studies have shown that CD14 is a bacterial lipopolysaccharide (LPS) binding glycoprotein, expressed as either a GPI-linked membrane protein or a soluble plasma protein (2). LPS induces an upregulation of GPI-linked CD14 expression, which facilitates TLR4 signaling and macrophage activation in response to bacterial infection (3-5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCD14; CD14 antigen; CD14 molecule; Monocyte differentiation antigen CD14; Monocyte differentiation antigen CD14, membrane-bound form; Monocyte differentiation antigen CD14, urinary form; Myeloid cell-specific leucine-rich glycoprotein\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H Mk\nSENSITIVITY: Endogenous\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800286679209,"sku":"75181T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-75181t","provider":"Iright","version":"1.0","type":"link"}