{"product_id":"cst-75243t","title":"CST,  75243T, PKN3 (F6S5C) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying PKN3. Validated for Western Blotting,Simple Western™. Available in 2 sizes. Highly specific and rigorously validated in-house, PKN3 (F6S5C) Rabbit Monoclonal Antibody (CST #75243) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nSimple Western™: 1:10 - 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPKN3 (F6S5C) Rabbit Monoclonal Antibody recognizes endogenous levels of total PKN3 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val882 of human PKN3 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nProtein Kinase N3 (PKN3) is a PKC-related protein kinase that acts downstream of Rho GTPases and PI3K, supporting tumor invasion, metastasis, and angiogenesis (1-3). PKN3 is highly expressed in cancer cells, and silencing PKN3 expression is under investigation as a means of treating human cancers (4). Atu027, a therapeutic siRNA that silences PKN3 expression in the vascular endothelium, has been shown to prevent or delay metastasis in human pancreatic cancer (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nPKN3; PKNBETA; protein kinase N3; Protein kinase PKN-beta; Protein-kinase C-related kinase 3; RP11-545E17.1; Serine\/threonine-protein kinase N3; UTDP4-1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 100\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799891038377,"sku":"75243T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-75243t","provider":"Iright","version":"1.0","type":"link"}