{"product_id":"cst-75330s","title":"CST,  75330S, Maoa (E3L3B) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying MAOA mouse. Validated for Western Blotting,IHC Leica Bond,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, Maoa (E3L3B) Rabbit Monoclonal Antibody (CST #75330) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nIHC Leica Bond: 1:800 - 1:3200\nImmunohistochemistry (Paraffin): 1:800 - 1:3200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, IHC Leica Bond, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMaoa (E3L3B) Rabbit Monoclonal Antibody recognizes endogenous levels of total Maoa protein. This antibody recognizes mouse Maoa protein and is also reactive with human MAOA protein; however, this antibody is not suggested for immunohistochemical analysis of human tissues. Nonspecific staining was observed in mouse testis by immunohistochemistry.\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala467 of mouse Maoa protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nMonoamine oxidase A (MAOA), a mitochondrial enzyme, catalyzes the degradation of monoamines. Studies show that increased expression of MAOA promotes prostate cancer metastasis by activating the Shh-IL6-RANKL signaling network (1). In addition, MAOA expression in adipose tissue macrophages is upregulated in aging, leading to the reduction of noradrenaline availability in adipose tissue. Decreased levels of noradrenaline contribute to the aging-related decline of catecholamine-induced lipolysis in adipocytes (2). Furthermore, sympathetic neuron-associated macrophages import and degrade norepinephrine via the transporter SLC6A2 and MAOA, respectively, and thus contribute to obesity (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n1110061B18Rik; AA407771; Amine oxidase [flavin-containing] A; AOFA; MAO-A; Maoa; MGC27811; monoamine oxidase A; Monoamine oxidase type A; OTTMUSP00000018396\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M\nSENSITIVITY: Endogenous\nMW (kDa): 62\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799891366057,"sku":"75330S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-75330s","provider":"Iright","version":"1.0","type":"link"}