{"product_id":"cst-75523s","title":"CST,  75523S, TAK-242","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nTAK-242 is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.38 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles .\n\u003cb\u003eBackground\u003c\/b\u003e\nTAK-242 is a small-molecule that specifically inhibits Toll-like receptor 4 signaling through binding to the intracellular domain of TLR4 at Cys747 (1). TLR4 triggers activation of the NF-κB, IRF-3, and MAPK pathways, leading to production of inflammatory cytokines. TAK-242 inhibits binding between TLR4 and adaptor molecules, including Toll\/interleukin-1 (IL-1) receptor domain-containing adaptor protein (TIRAP), which blocks activation of NF-κB and other downstream signaling events (2). In LPS-stimulated mouse macrophages, TAK-242 suppressed the production of NO and the inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) (3). In a study of LPS-induced myotube atrophy, TAK-242 provides a protective effect by inhibiting TLR4 and suppressing TNF-α- and IL-6-mediated inflammatory responses. Similar results were seen in a mouse model of endotoxemia, with TAK-242 inhibiting activation of inflammatory and proteolytic pathways and reversing the muscle wasting impact induced by LPS treatment (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n(R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate; CLI-095; Resatorvid","brand":"CST","offers":[{"title":"Default Title","offer_id":46800698212521,"sku":"75523S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-75523s","provider":"Iright","version":"1.0","type":"link"}