{"product_id":"cst-76069s","title":"CST,  76069S, CD21\/CR2 (2G9) Mouse Monoclonal Antibody","description":"Monoclonal Antibody for studying CR2. Validated for IHC Leica Bond,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, CD21\/CR2 (2G9) Mouse Monoclonal Antibody (CST #76069) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nIHC Leica Bond: 1:200 - 1:800\nImmunohistochemistry (Paraffin): 1:50 - 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied as liquid tissue culture supernatant containing sodium azide as a preservative. Stable for 6 months when stored at 4°C. Do not aliquot the antibody. Note: This product is only available in the format listed above. We are unable to provide this in a carrier free, custom formulation.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: IHC Leica Bond, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCD21\/CR2 (2G9) Mouse Monoclonal Antibody recognizes endogenous levels of CD21\/CR2 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a prokaryotic recombinant protein corresponding to the external domain of human CD21\/CR2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nComplement receptor type 2 (CD21\/CR2) is a type 1 transmembrane glycoprotein whose expression is largely restricted to B lymphocytes and follicular dendritic cells (1,2). Research studies have shown that CD21\/CR2 functions to bind the complement fragments iC3b, C3dg, and C3d, which function to activate the alternative complement pathway and MAC formation (3,4). In addition to its function as a complement receptor, CD21\/CR2 also functions as the B lymphocyte receptor for Epstein-Barr virus (5) and interferon alpha (6). Research studies have also shown that CD21\/CR2 participates in B cell activation, proliferation, and protection from apoptosis through its association with components of the B cell coreceptor signaling complex such as CD19 and CD21 (7-9).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nC3DR; CD21; Complement C3d receptor; complement C3d receptor 2; complement component (3d\/Epstein Barr virus) receptor 2; complement component 3d receptor 2; Complement receptor type 2; CR; CR2; CVID7; EBV receptor; Epstein-Barr virus receptor; SLEB9\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nSource\/Isotype: Mouse IgG2a","brand":"CST","offers":[{"title":"Default Title","offer_id":46800286908585,"sku":"76069S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-76069s","provider":"Iright","version":"1.0","type":"link"}