{"product_id":"cst-76213s","title":"CST,  76213S, CLEC4A (F2X3I) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CLEC4A. Validated for Western Blotting,Flow Cytometry (Live). Available in 2 sizes. Highly specific and rigorously validated in-house, CLEC4A (F2X3I) Rabbit Monoclonal Antibody (CST #76213) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nFlow Cytometry (Live): 1:100 - 1:400\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Flow Cytometry (Live)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCLEC4A (F2X3I) Rabbit Monoclonal Antibody recognizes endogenous levels of total CLEC4A protein. This antibody detects a 65 kDa and a 100 kDa protein of unknown identity in some cell lines.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn200 of human CLEC4A protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nC-type lectin domain family 4 member A (CLEC4A), also referred to as dendritic cell (DC) immunoreceptor (DCIR), is a type II membrane glycoprotein, primarily expressed on myeloid-derived cells including monocytes, DCs, macrophages, and neutrophils (1-4). CLEC4A contains an ITIM motif in the cytoplasmic domain, which is involved in regulating immune response (1,2,5). CLEC4A provides anti-inflammatory signaling through the recruitment of phosphatases SHP-1 and SHP-2 (3-5). Insufficient CLEC4A function might cause autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) (4,5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nC-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6; C-type lectin DDB27; C-type lectin domain family 4 member A; C-type lectin superfamily member 6; CD367; CLC4A; CLEC4A; CLECSF6; DCIR; DDB27; Dendritic cell immunoreceptor; HDCGC13P; Lectin-like immunoreceptor; LLIR\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 30-40\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799895658665,"sku":"76213S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-76213s","provider":"Iright","version":"1.0","type":"link"}