{"product_id":"cst-76290t","title":"CST,  76290T, DPEP-1\/MDP (E5C2V) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying DPEP1. Validated for Western Blotting,Immunofluorescence (Immunocytochemistry). Available in 2 sizes. Highly specific and rigorously validated in-house, DPEP-1\/MDP (E5C2V) Rabbit Monoclonal Antibody (CST #76290) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunofluorescence (Immunocytochemistry): 1:400 - 1:1600\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunofluorescence (Immunocytochemistry)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nDPEP-1\/MDP (E5C2V) Rabbit Monoclonal Antibody recognizes endogenous levels of total DPEP-1\/MDP protein. This antibody does not cross-react with either DPEP-2 or DPEP-3 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro312 of human DPEP-1\/MDP protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nDipeptidase-1 (DPEP-1, RDP, MDP) is a GPI-linked glycoprotein expressed in the epithelial brush border of the kidney epithelium and exists as a disulfide-linked homodimer (1). Research studies have shown that the enzymatic activity of DPEP-1 is involved in kidney metabolism of glutathione, leukotrienes, and β-lactam antibiotics (2,3). Independent of its enzymatic activity, DPEP-1 has been implicated in pathologic inflammation by acting as an adhesion receptor for neutrophils on endothelial cells within the lung (4). DPEP-1 has also been implicated in human cancer and numerous studies have demonstrated that expression of this enzyme is upregulated in colorectal cancer and promotes metastasis (5-7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nBeta-lactamase; Dehydropeptidase-I; Dipeptidase 1; dipeptidase 1 (renal); DPEP1; hRDP; MBD1; MDP; Microsomal dipeptidase; RDP; Renal dipeptidase; testicular tissue protein Li 57\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 58\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799896248489,"sku":"76290T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-76290t","provider":"Iright","version":"1.0","type":"link"}