{"product_id":"cst-76536t","title":"CST,  76536T, CARD14 (E3F8E) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CARD14. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, CARD14 (E3F8E) Rabbit Monoclonal Antibody (CST #76536) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCARD14 (E3F8E) Rabbit Monoclonal Antibody recognizes endogenous levels of total CARD14 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn96 of human CARD14 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCARD14 (caspase recruitment domain-containing protein 14) is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, functioning as molecular scaffolds for the assembly of multiprotein complexes (1-3). CARD14 has been shown to regulate BCL10 function, leading to NF-κB activation (1-3). It also induces activation of p38 and JNK MAP kinase pathways via interaction with MALT1 (4). Full-length CARD14, CARD14fl or isoform 1, encodes both an N-terminal CARD domain necessary for NF-kB activation, and a C-terminal tripartite MAGUK domain (PDZ\/SH3\/GUK). A shorter isoform, CARD14sh, encodes the CARD domain but not the tripartite domain (1,2). Mutations of are associated with psoriasis and psoriatic arthritis (2,3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nbcl10-interacting maguk protein 2; BIMP2; CAR14; CARD-containing MAGUK 2 protein; CARD-containing MAGUK protein 2; card-maguk protein 2; CARD14; Carma 2; CARMA2; caspase recruitment domain family member 14; caspase recruitment domain family, member 14; Caspase recruitment domain-containing protein 14; PRP; PSORS2; PSS1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 120-140\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799897264297,"sku":"76536T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-76536t","provider":"Iright","version":"1.0","type":"link"}