{"product_id":"cst-76703s","title":"CST,  76703S, RGS14 (E4N2Q) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying RGS14 mouse. Validated for Western Blotting,Immunofluorescence (Frozen). Available in 2 sizes. Highly specific and rigorously validated in-house, RGS14 (E4N2Q) Rabbit Monoclonal Antibody (CST #76703) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunofluorescence (Frozen): 1:3200 - 1:6400\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 74575 .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunofluorescence (Frozen)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nRGS14 (E4N2Q) Rabbit Monoclonal Antibody recognizes endogenous levels of total RGS14 protein. Non-specific staining in fixed frozen mouse kidney may be observed by immunofluorescence.\nSpecies Reactivity: Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of mouse RGS14 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nRegulator of G-protein signaling (RGS) proteins are a structurally diverse family of more than 30 member proteins enriched in brain that typically limit neurotransmitter receptor- and G protein-linked signaling in the CNS and elsewhere by serving as GTPase-activating proteins (GAPs) (1). RGS14 is a multifunctional signaling protein that regulates post-synaptic plasticity in neurons and acts as a scaffolding protein that integrates G protein, Ras\/ERK, and calcium\/calmodulin signaling pathways essential for spine plasticity and cell signaling (2). It is highly enriched within pyramidal cells of hippocampal area CA2, allowing RGS14 to naturally suppress long-term potentiation (LTP) and structural plasticity in that region (2-4). RGS14 has been shown to directly interact with two key Ca -activated proteins in CA2 neurons: calcium\/calmodulin and CaMKII (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nrap1\/rap2 interacting protein; RAP1\/RAP2-interacting protein; Regulator of G-protein signaling 14; RGS14; RPIP1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M R\nSENSITIVITY: Endogenous\nMW (kDa): 65\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800122347689,"sku":"76703S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-76703s","provider":"Iright","version":"1.0","type":"link"}