{"product_id":"cst-76892s","title":"CST,  76892S, TREX1 Antibody","description":"Polyclonal Antibody for studying TREX1 mouse. Validated for Western Blotting. Highly specific and rigorously validated in-house, TREX1 Antibody (CST #76892) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nTREX1 Antibody recognizes endogenous levels of total TREX1 protein.\nSpecies Reactivity: Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val94 of mouse TREX1 protein. Antibodies are purified by peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nTREX1 is a broadly expressed 3' to 5' exonuclease that acts on single-stranded DNA (ssDNA) to negatively regulate the interferon-stimulatory DNA (ISD) response (1-4). Three human TREX1 isoforms are generated through alternative splicing and have predicted molecular weights of 32 kDa, 33 kDa, and 39 kDa (2). The transcript for the 33 kDa isoform is the most abundant (2). TREX1-deficient mice accumulate intracellular ssDNA, which triggers the ISD response, ultimately resulting in lethal autoimmunity (3,4). mutations are associated with autoimmune diseases, including Aicardi-Goutieres syndrome and systemic lupus erythematosus (5,6). Additionally, TREX1 prevents the cell-intrinsic innate immune response to human immunodeficiency virus (HIV) by degrading excess HIV DNA that would otherwise trigger a type I interferon induction (7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n1661; 3'-5' exonuclease TREX1; AU041952; DNase III; OTTMUSP00000022432; OTTMUSP00000022433; three prime exonuclease 1; Three prime repair exonuclease 1; Three-prime repair exonuclease 1; Trex1; trophoblast expressed 1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M\nSENSITIVITY: Endogenous\nMW (kDa): 33\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46800122937513,"sku":"76892S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-76892s","provider":"Iright","version":"1.0","type":"link"}